This idea is in line with direct, recent demonstrations in other studies of rabbit SANC of the key role of NCX in normal pacemaker function.
The finding that other major currents, I CaL, I f, and I Kr, contributing to the diastolic depolarization, do not fail under ischemic-like conditions, whereas NCX does, suggests that the latter is critical to the normal pacemaker function.
Since previous studies demonstrated a minor role of I CaT in normal pacemaker function of rabbit SANC, the reduction in I NCX rather than that in I CaT is likely the major mechanism in the simulated ischemia-induced bradycardia. However, the extent to which each of these reductions contributes to bradycardia was not determined. mnt-by: RIPE-NCC-HM-MNT created: last-modified: source: RIPE % Information related to 'AS28753' % Abuse contact for 'AS28753' is aut-num: AS28753 as-name: LEASEWEB-DE-FRA-10 remarks: remarks: - LeaseWeb Peering Network remarks: mp-import: from AS16265 accept ANY mp-export: to AS16265 announce AS-LEASEWEB-DE import: from AS16265 accept ANY export: to AS16265 announce AS-LEASEWEB-DE remarks: remarks: - TRANSIT remarks: mp-import: from AS1299 accept ANY mp-export: to AS1299 announce AS-LEASEWEB-DE import: from AS1299 accept ANY export: to AS1299 announce AS-LEASEWEB-DE org: ORG-nA8-RIPE admin-c: LSWG-RIPE tech-c: LSWG-RIPE status: ASSIGNED mnt-by: RIPE-NCC-END-MNT mnt-routes: LEASEWEB-DE-MNT mnt-by: LEASEWEB-DE-MNT created: last-modified: source: RIPE organisation: ORG-nA8-RIPE org-name: Leaseweb Deutschland GmbH org-type: LIR address: Kleyerstrasse 75-87 address: 60326 address: Frankfurt am Main address: GERMANY phone: +496924752860 fax-no: +496924752861 admin-c: LSWG-RIPE admin-c: SPW1-RIPE abuse-c: LWGA-RIPE mnt-ref: RIPE-NCC-HM-MNT mnt-ref: LEASEWEB-DE-MNT mnt-by: RIPE-NCC-HM-MNT mnt-by: LEASEWEB-DE-MNT created: last-modified: source: RIPE # Filtered person: RIPE Mann address: Kleyerstrasse 75-87 address: 60326 Frankfurt am Main address: Germany phone: +49 69 2475 2860 fax-no: +49 69 2475 2861 nic-hdl: LSWG-RIPE mnt-by: LEASEWEB-DE-MNT created: last-modified: source: RIPE # Filtered % This query was served by the RIPE Database Query Service version 1.91.The study by Du and Nathan in this issue of Journal of Molecular and Cellular Cardiology suggests that simulated ischemia-induced bradycardia in rabbit SANC is caused, at least in part, by a failure (i.e., reduction) of two ion currents I CaT and I NCX.
% Information related to 'AS28699 - AS28912' as-block: AS28699 - AS28912 descr: RIPE NCC ASN block remarks: These AS Numbers are assigned to network operators in the RIPE NCC service region. % To receive output for a database update, use the "-B" flag. % See % Note: this output has been filtered. % % The RIPE Database is subject to Terms and Conditions. % This is the RIPE Database query service.